Fred Kavli Plenary Lecture
The Kavli Foundation, based in Oxnard, California, is dedicated to the goals of advancing science for the benefit of humanity and promoting increased public understanding and support for scientists and their work. The Foundation’s mission is implemented through an international program of research institutes, professorships, and symposia in the fields of astrophysics, nanoscience, neuroscience, and theoretical physics as well as prizes in the fields of astrophysics, nanoscience and neuroscience. To learn more about their foundation, please visit their website: http://www.kavlifoundation.org .
2015 Plenary Lecture
The 2015 Fred Kavli Foundation Plenary Lecturer is:
Ann Graybiel, PhD
- Massachusetts Institute of Technology
“The basal ganglia: heartland of neuroeconomics”
Regions of the medial prefrontal cortex are known to function in organizing behavior and emotional decision-making, both key functions disturbed in a range of neurologic and neuropsychiatric disorders. In our laboratory, we are seeking to understand mechanisms underlying these functions by applying optogenetic manipulations and microstimulation to these regions and their corticostriatal circuits. We find that we can interrupt the transition from deliberative decision-making to a habitual mode of decisions to act, and can interrupt habitual and insistently repetitive behaviors. In other experiments, we can selectively disrupt decision-making under different contexts involving weighing the costs and benefits of such choices. These experiments point to profoundly important functions of corticostriatal circuits and to their exquisite specialization. These features could be critical in linking these corticostriatal circuit mechanisms to human disorders in which value-based decision-making is affected.
2014 Plenary Lecture
The 2014 Fred Kavli Foundation Plenary Lecturer is:
Colin Camerer, PhD
- Robert Kirby Professor of Behavioral Finance and Economics at the California Institute of Technology
- 2013 MacArthur Fellow
“The Neuroeconomics of Complex Social Valuation”
The creation of mechanistic neural models of choice computation can come from bottom-up or top-down. I start with classic topics from the social science of collective behavior. In each of these topics, there are long-standing puzzles that do not appear to be easily resolved by simply observing more behavior. The approach discussed in this talk is therefore unapologetically top-down: We start with behavioral observation, hypothesize a biological cause for the behavior and investigate that cause at an intermediate level (e.g., neural circuitry), with whatever method is appropriate for understanding the intermediate level. Three examples illustrate this approach: the influence of affiliative hormones (AVP) on risky cooperation; bargaining with private information (behavior and fMRI); and the formation and crash of asset price bubbles (fMRI).
2013 Plenary Lecture
The 2013 Fred Kavli Foundation Plenary Lecturer is:
Vernon L. Smith, PhD
- Professor of Economics and Law, Chapman University
- Nobel Laureate in Economics, 2002
“Adam Smith: From Propriety and Sentiments to Property and Wealth”
“Why return to Adam Smith?” Because we learn that he had fresh-for-today insights, derived from a modeling perspective that was never part of economic analysis. Smith wrote two classics: The Theory of Moral Sentiments (1759; hereafter Sentiments); and An Inquiry into the Nature and Causes of the Wealth of Nations (1776; hereafter Wealth). In Sentiments it is argued that human sociability in close-knit groups is governed by the “propriety and fitness” of conduct based on sympathy (that surely influenced Darwin). This non-utilitarian model provides new insights into the results of 2-person experimental “trust” and other games that defied the predictions of traditional game theory in the 1980s and 90s, and offers testable new predictions. Moreover, Smith shows how the civil order of “property” grew naturally out of the rules of propriety. Property together with what I call Smith’s Discovery Axiom then enabled his break-through in Wealth that defined the liberal intellectual and practical foundation of two centuries of Western economic growth.
2012 Plenary Lecture
The 2012 Fred Kavli Foundation Plenary Lecturer is:
William T. Newsome, PhD
- Professor, Neurobiology, Stanford University School of Medicine
- Investigator, Howard Hughes Medical Institute
“A new look at gating: Selective Integration of sensory signals through network dynamics”
A hallmark of decision-making in primates is contextual sensitivity: a given stimulus can lead to different decisions depending on the context in which it is presented. This kind of flexible decision-making depends critically upon gating and integration of context-appropriate information sources within the brain. We have analyzed neural mechanisms underlying gating and integration in animals trained to perform a context-sensitive decision task. Surprisingly, both relevant and irrelevant sensory signals are present within frontal lobe circuits that form decisions, implying that gating occurs very late in the process. Dynamical systems analysis of the neural data, combined with a dynamical recurrent network model, suggests a novel mechanism by which gating and integration are combined in a single process.
2011 Plenary Lecture
The 2011 Kavli Foundation Plenary Lecturer is:
Professor Antonio Damasio
- University Professor, Dornsife Professor of Neuroscience
- Director of USC’s Brain and Creativity Institute.
“About the Neural Basis of Feelings”
A reflection on recent advances and questions on the neuroscience of feelings, with an emphasis on the different neural platforms required for sensing affective states.
2010 Plenary Lecture
At our 2010 Society for Neuroeconomics conference, we were proud to have the first Kavli sponsored lecture:
The Kavli Foundation Plenary Lecture:
Professor Wolfram Schultz, MD, PhD, FRS
- Department of Physiology, Development & Neuroscience, University of Cambridge, UK
“Predictive, subjective and adaptive coding of reward value and risk”
We investigated basic neuronal reward and risk processes important for decision making using neurophysiological methods in monkeys and brain imaging in humans.
Informed decisions between different rewards are based on predictions about future outcomes. We investigated the nature of reward predictive neuronal signals in the amygdala by manipulating the informative nature of the predictive stimulus. We changed the contextual background reward while keeping stimulus reward constant. True reward predictive responses reflected the difference between background and stimulus reward, suggesting that reward contingency rather than simple stimulus-reward pairing (contiguity) determined the predictive neuronal responses.
Reward value appears to depend on the individual decision maker and the environment, and hence is subjective. Dopamine neurons in monkeys, and likely downstream striatal activations in humans, discounted reward value across temporal delays of a few seconds despite unchanged objective reward value, suggesting subjective value coding.
Reward predictions inform about probability distributions of reward values with varying degrees of risk. Subpopulations of orbitofrontal and striatal neurons, and most dopamine neurons, showed adaptation of reward related responses to the mean and variance (risk) of predicted probability distributions of reward value. These data suggest matching of distributions between neuronal output responses and reward input, resulting in effective reward coding akin to sensory adaptation. Adaptive teaching signals provide stability of learning and established performance in noisy environments. Adaptive neuronal coding may explain such behavioural phenomena as reference dependent coding.
The processing of risky outcomes depends on the subjective perception of risk and, separately, on the personal attitudes of individual decision makers towards risk. Dopamine and orbitofrontal neurons in monkeys showed distinct risk signals that were unlikely to constitute value or utility signals. In humans, risk signals and the influence of risk on value signals covaried with individual risk attitudes in subregions of prefrontal cortex, suggesting subjective coding of risk and its influence on reward value.
Taken together, these data demonstrate the nature of neuronal reward predictions and suggest subjective coding of key reward variables via temporal delays and adaptive processes in main reward structures of the brain.